Matrix: VDOL/tumorAntiAngiogenesis_7

Description: tumorAntiAngiogenesis optimal control problem (matrix 7 of 8)

 (undirected graph drawing)

• Home page of the UF Sparse Matrix Collection
• Matrix group: VDOL
• Click here for a description of the VDOL group.
• Click here for a list of all matrices
• Click here for a list of all matrix groups
• download as a MATLAB mat-file, file size: 65 KB. Use UFget(2754) or UFget('VDOL/tumorAntiAngiogenesis_7') in MATLAB.
• download in Matrix Market format, file size: 33 KB.
• download in Rutherford/Boeing format, file size: 30 KB.

 Matrix properties number of rows 475 number of columns 475 nonzeros 4,597 structural full rank? yes structural rank 475 # of blocks from dmperm 1 # strongly connected comp. 1 explicit zero entries 0 nonzero pattern symmetry symmetric numeric value symmetry symmetric type real structure symmetric Cholesky candidate? no positive definite? no

 author B. Senses, A. Rao editor T. Davis date 2015 kind optimal control problem 2D/3D problem? no

 Additional fields size and type b full 475-by-1 rowname full 475-by-80 mapping full 475-by-1

Notes:

```Optimal control problem, Vehicle Dynamics & Optimization Lab, UF
Anil Rao and Begum Senses, University of Florida
http://vdol.mae.ufl.edu

This matrix arises from an optimal control problem described below.
Each optimal control problem gives rise to a sequence of matrices of
different sizes when they are being solved inside GPOPS, an optimal
control solver created by Anil Rao, Begum Senses, and others at in VDOL
lab at the University of Florida.  This is one of the matrices in one
of these problems.  The matrix is symmetric indefinite.

Rao, Senses, and Davis have created a graph coarsening strategy
that matches pairs of nodes.  The mapping is given for this matrix,
where map(i)=k means that node i in the original graph is mapped to
node k in the smaller graph.  map(i)=map(j)=k means that both nodes
i and j are mapped to the same node k, and thus nodes i and j have
been merged.

This matrix consists of a set of nodes (rows/columns) and the
names of these rows/cols are given

Anil Rao, Begum Sense, and Tim Davis, 2015.

VDOL/tumorAntiogenesis

Tumor anti-angiogenesis optimal control problem is taken from
Ref.~\cite{ledzewicz2008analysis}. A tumor first uses the blood
vessels of its host but as the tumor grows oxygen that is carried by
the blood vessels of its host cannot defuse very far into the tumor.
Therefore, the tumor grows its own blood vessels by producing
vascular endothelial growth factor (VEGF). This process is called
angiogenesis. But blood vessels have a defense mechanism, called
endostatin, that tries to impede the development of new blood cells
by targeting VEGF. In addition, new pharmacological therapies that is
developed for tumor-type cancers also targets VEGF. The goal of the
tumor anti-angiogenesis problem is to determine the state and control
that minimizing the size of the tumor at the final time. The state of
the system is defined by the tumor volume, carrying capacity of a
vessel, and the total anti-angiogenic treatment administered and the
control of the system is the angiogenic dose rate.  The specified
accuracy tolerance of \$10^{-7}\$ were satisfied after eight mesh
iterations. As the mesh refinement proceeds, the size of the KKT
matrices increases from 205 to 490.

@article{ledzewicz2008analysis,
title={Analysis of Optimal Controls for a Mathematical Model of
Tumour Anti-Angiogenesis},
author={Ledzewicz, Urszula and Sch{\"a}ttler, Heinz},
journal={Optimal Control Applications and Methods},
volume=29,
number=1,
pages={41--57},
year=2008,
publisher={Wiley Online Library}
}
```

 Ordering statistics: result nnz(chol(P*(A+A'+s*I)*P')) with AMD 4,213 Cholesky flop count 4.6e+04 nnz(L+U), no partial pivoting, with AMD 7,951 nnz(V) for QR, upper bound nnz(L) for LU, with COLAMD 25,900 nnz(R) for QR, upper bound nnz(U) for LU, with COLAMD 111,811

For a description of the statistics displayed above, click here.

Maintained by Tim Davis, last updated 04-Jun-2015.
Matrix pictures by cspy, a MATLAB function in the CSparse package.
Matrix graphs by Yifan Hu, AT&T Labs Visualization Group.